- Larger birds of prey: Golden eagles, bald eagles, and other large raptors can prey on smaller hawks and eagles.
- Owls: Great horned owls and other large owls can hunt and kill hawks and eagles, especially at night when the latter are less active.
- Falcons: Peregrine falcons and other fast-flying falcons can catch and kill hawks and eagles in mid-air.
- Bears: Bears, such as grizzly bears and black bears, are opportunistic predators that may prey on hawks and eagles that nest or hunt in their territory.
- Wolves: Wolves may occasionally kill and eat hawks and eagles, especially if the birds are injured or sick.
- Mountain lions: Mountain lions are known to prey on a variety of birds, including hawks and eagles.
- Bobcats: Bobcats may occasionally prey on smaller hawks and eagles.
- Coyotes: Coyotes may prey on hawks and eagles that nest or hunt on the ground.
- Raccoons: Raccoons may raid hawks' and eagles' nests and eat their eggs or young.
- Other predators: Snakes, such as rattlesnakes, and other predators, such as wolverines and martens, may occasionally prey on hawks and eagles.