Instructions
Take your queen --- the breeding female --- to the veterinarian. Check her overall health and discuss the best nutrition to prepare your cat for pregnancy and support the unborn kittens.
Choose a large male. The Maine coon and Siberian are both large breeds. The Savannah is a newer breed and, because it is a cross-breed, some male Savannah cats are sterile.
Sequester the queen from other cats. Not only does this protect your queen's health, but it also ensures that she will only mate with the male of your choice. When the female starts the low growl of heat, introduce the male. Some cats are picky. They may need to spend some time together before the queen allows mating to take place.
Purchase or make a birthing box. This can be as simple as a cardboard box with soft rags. Most cats give birth without help.
Take the queen and kittens to the veterinarian for a full check up after birth.
How to Breed Large House Cats
With the large number of unwanted kittens born every year, breeding a cat intentionally is an important decision. Large house cats often produce large offspring. There are several large breeds to choose from, including Maine coon cats, which can grow up to 20 pounds, and Siberian cats. According to the American Cat Fanciers, the Siberian may take up to five years to fully mature, which will affect successful breeding. A new large house cat breed is the Savannah. This is a cross-breed of the serval, a small, African wildcat, and a domestic breed. Considered house cats, Savannahs require no special license, but often preserve their ancestor's wild looks and can grow to 30 pounds.