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Diphenhydramine
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Diphenhydramine (Benadryl®) is an antihistamine that is used to treat allergies, and it also inhibits nausea and dizziness. It will make your pet drowsy. It is generally safe and effective, but should not be given to pregnant or nursing animals. It's also not recommended for cats with glaucoma, lung disease, heart disease, thyroid problems or high blood pressure. It is available over the counter, but talk to your vet about the proper dosage for your animal.
Dimenhydrinate
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Dimenhydrinate (Dramamine®) is another antihistamine that is effective in preventing motion sickness. It is not recommended for cats that have an overactive thyroid, seizures, heart disease or high blood pressure. Also, it may interact with other medications, such as tranquilizers and sedatives. This medication is designed for humans, so discuss proper dosage with your vet.
Herbal Remedies
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Homeopathic and herbal treatments have been developed as alternatives to traditional medications. They generally include ginger and mint to relieve nausea, as well as other compounds that may reduce anxiety. The Veterinary Botanical Medical Association advises pet owners to obtain herbal remedies from companies that belong to the National Animal Supplement Council, which sets policies and procedures on adverse event reporting and quality control.
Tranquilizers and Sedatives
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Cats that suffer from severe motion sickness may need prescription medications. Acepromizine is a tranquilizer that depresses the central nervous system. It is a veterinary drug that can be obtained by prescription only. Phenobarbital is a barbiturate designed for humans. It is a controlled substance and must be prescribed by a veterinarian with a license from the Drug Enforcement Administration.
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What Medications Can a Cat Have for Car Travel?
Some cats get motion sickness when traveling in a car. Symptoms include yawning, excessive drooling and vomiting. If your pet can't adjust to riding in the car, medications are available that will make road trips more comfortable for both of you. Consult your veterinarian about these options; it is never a good idea to guess about how much medication to give your pet.