Cushing's disease, medically termed as hyperadrenocorticism, is a condition in which the adrenal gland produces excessive amounts of glucocorticoids, such as cortisol (see reference 1). Approximately 80 percent of affected cats are suffering from Cushing's disease because of a tumor in the pituitary gland, which controls the adrenal gland.
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Increases
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Cats suffering from hyperadrenocorticism will display an increase in their appetite (polyphagia), an increase in thirst (polydipsia) and an increase in urination (polyuria). (See references 1, 2, and 3.)
Fragile Skin Syndrome
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Cushing's disease can cause thinning of the skin in cats, which may also be termed as fragile skin syndrome.
Changes in Weight
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Many cats will also suffer from either weight gain or weight loss. Weight loss could also be a sign of muscle wasting.
Hair Loss
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Feline hyperadrenocorticism may cause hair loss, which may be symmetrical in appearance.
Additional Symptoms
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Additional signs and symptoms of feline Cushing's disease include bloating, excessive panting, a dull or dry coat, diabetes, muscle weakness, lethargy and reoccurring infections (see references 1, 2, and 3).
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