How long after birth of puppies will female come in heat again?

It depends on the breed and individual dog, but generally, female dogs will come back into heat around 4-6 months after giving birth.

Here's a more detailed breakdown:

* Smaller breeds often come back into heat sooner, sometimes as early as 3 months.

* Larger breeds might take a bit longer, up to 7-8 months.

* Nursing mothers can sometimes experience a delayed return to heat, as their hormones are still adjusting.

Important Note: This is a general guideline. Always consult with your veterinarian to get specific advice for your dog. They can help you understand the typical heat cycle for your breed and individual dog, and monitor for any unusual changes.