Instructions
Take both the sire and the dame to the veterinarian for a complete physical examination. Ask your veterinarian to check for possible signs of deafness, heart conditions, hemophilia, digestive problems, epilepsy, allergies, and brucellosis. A positive brucellosis test will indicate the pair will be unable to reproduce. Brucellosis is one of the main causes of sterility in dogs.
Check both the dame and sire for temperament. Never breed a Great Dane with an ill temper. Breeding one that is insecure, or aggressive around people or other animals results in the degeneration of the Great Dane, and only adds to personality issues. Breed Great Danes that are healthy, happy, energetic, and obedient.
Research the pedigree and bloodline of both dogs prior to breeding. Consider the color, size, and physical traits of the sire and dame. Traits and genes play a large role in the appearance of the pups.
Allow the pair to be alone in an enclosed area. If the dame is in heat, and the sire is ready, they will mate on their own. The actual physical connection will take between five and 30 minutes. There is nothing that can force breeding; it will happen naturally.
How to Mate Great Danes
According to the American Kennel Club, the Great Dane is an established dog breed believed to have existed in both Ancient Egypt and China. The modern line originated as a German boar-hunting dog, and were later used as guard dogs. Each mating pair of Great Danes should have certain physical and mental characteristics -- including personality, temperament, health, age, and fertility.