Renal disease in dogs occurs when the kidneys fail to do their job of filtering the blood, removing certain toxins and retaining certain minerals and electrolytes. Renal adenomas, however, are very rare in dogs, affecting mostly the males. An adenoma is a benign tumor that could very quickly become malignant and metastasize. Diagnosing your dog early can help ensure a better outcome. After the adenoma tumor is excised, there are several drugs available to treat your dog and provide for a better quality of life.
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Cisplatin
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Cisplatin is an anticancer drug that has the capability to interrupt the DNA in tumor cells, killing the bad cells. Cisplatin, also known as Platinol, is given intravenously, along with plenty of fluids to promote urination and protect the kidney functions.
Piroxicam
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According to Wedgewoodpetrx.com, Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) that is used on dogs and cats to treat various urinary and renal adenomas. Piroxicam has proven to allow the kidneys to protect the GI tract, while killing cancerous cells and disrupting tumor growth.
Mitoxantrone
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Mitoxantrone has known antitumor properties against canine renal and bladder cancers, with less toxicity and fewer side effects. This drug is given intravenously over a 21-day period, with minimal success of about 30 percent when used alone.
Vincristine
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Vincristine works by killing the tumor's cancer cells and sparing the good cells, cutting off the blood supply to the tumor as well. Vincristine has the unexplained ability to cause a sudden release of platelets to good cells, and is often used as part of a multidrug protocol for the treatment of tumors.
Actinomycin D
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Actinomycin D administered through injection has proven to reestablish normal flow of the kidneys within an hour of the injection. It is a benefit in drug therapy for renal adenoma due to higher drug retention in the tumor tissue.
Multidrug Combinations
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Mitoxantrone/piroxicam used together induce remission more frequently than previously reported for either drug used alone against canine renal adenoma. Mitoxantrone is administered intravenously every three weeks for four treatments; piroxicam is given orally every day.
Cisplatin/piroxicam used together have also proven to induce a quicker remission than either agent alone.
Vincristine/Actinomycin D work to kill bad cells and provide ample supply of new blood platelets to the good cells, while keeping the kidneys functioning to optimum capacity.
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