Side Effects of Antifungal Medication for Dogs

A variety of drugs are available to treat fungus in animals. Which type of medication used depends on the fungus. Some treat ringworm, while others treat fungal infections such as blastomycosis and cryptococcosis. While generally safe, anti-fungal medications can cause certain side effects that a veterinarian should address it they occur.

  1. Jaundice

    • According to the Pet Place website, jaundice is a side effect that quite a few anti-fungal medications can cause. Such medications include ketoconazole and fluconazole. The symptoms of jaundice include yellowing of the skin, eyes and mucous membranes. A dog experiencing jaundice may also vomit, have diarrhea and a decrease in appetite.

    Gastrointestinal Issues

    • A number of anti-fungal medications can cause gastrointestinal upset in animals. Affected dogs typically vomit and have diarrhea. Some may also have a decrease in their appetites. Anti-fungal medications that often cause these symptoms include griseofulvin, fluconazole and ketoconazole.

    Drug Interactions

    • Certain anti-fungal drugs can cause interactions with other medications your dog might take, states the Pet Place website. Fluconazole can interact with certain antibiotics, cyclosporine and glipizide. Ketoconazole can react with certain medications as well. Dogs that currently take methylprednisone, cisapride, antacids, heart medications, anticonvulsants, theophylline, cimetidine and cyclosporine should not take ketoconazole.

    Lethargy and Depression

    • Certain anti-fungal medications can cause depression and lethargy in some dogs. Ketoconazole affects the hormone levels of dogs, particularly cortisone, testosterone and other sex hormones. Because of this, it may change the dog’s reproductive abilities and leave him depressed or lethargic.

    Change in Appearance

    • The Pet Place website states that ketoconazole can change the coat of a dog. Affected canines may experience a lightening of the hair color.