Cushing's disease is known as hyperadrenocorticism and is caused by the overproduction of the hormone cortisol by the adrenal glands, according to Washington State University's College of Veterinary Medicine. The adrenal glands' increased cortisol production is most likely caused by tumors on either the pituitary or adrenal glands. Tumors on the pituitary gland increase ACTH hormone production, which, in turn, signals the brain to tell the adrenals to produce more cortisol. Eighty percent of dogs suffer from pituitary-related Cushing's disease, and Lysodren is a commonly prescribed medication.
-
Allergies
-
If the dog is allergic to Lysodren, its face may begin to swell and it may break out in hives; sudden and constant scratching is a good indicator that the animal is suffering from a hives breakout. Other signs of an allergic reaction vary in degree of severity and include intense and sudden vomiting and/or diarrhea, shock and/or seizing, pale gums, cold limbs and, if the dog is severely allergic to Lysodren, it may slip into a coma.
Decreased Appetite
-
The dog's appetite may decrease immediately upon taking Lysodren, or slowly over time. This may be a good thing in some cases because Cushing's disease can cause an unhealthy increase in the dog's appetite, thirst and urination. Other times, the medication may make the dog nauseated and cause vomiting, diarrhea (aside from an allergic reaction) and a loss in the dog's desire to eat.
Depression/Lethargy
-
Another side effect of Lysodren is an overall weakness. The dog may become lethargic and/or depressed. It may also experience weakness and lose its coordination. This can be frightening and frustrating for both the dog and its owner, as behavioral changes are often unexpected and cannot be explained.
Liver Damage
-
Loss of appetite may be an actual side effect of Lysodren or may also signify a more severe side effect of Lysodren. If the owner notices the dog's skin, gums or the whites of its eyes turning yellow, the dog may be suffering from jaundice, a symptom of liver damage. Therefore, Lysodren should be used with caution in dogs that already have compromised liver function.
-