Canine Cushing's disease occurs when levels of the hormone cortisol become elevated in a dog's body. The medication trilostane is effective at treating one type of canine Cushing's disease.
-
Background
-
Approximately 85 percent of canine Cushing's disease is caused by pituitary-dependent hyperadrenocorticism (PDH), which occurs when the dysfunction of the pituitary gland causes levels of cortisone to become too high, reports Wedgewood Pharmacy. Trilostane only treats Cushing's caused by this condition.
Function
-
Trilostane works by interfering with an enzyme called 3-beta-hydroxysteroid dehydrogenase, which contributes to the production of both pituitary hormones and cortisol.
Effects
-
Dogs suffering from canine Cushing's disease caused by PDH who receive treatment with trilostane typically experience a reduction in symptoms like increased thirst, urination and appetite, according to Wedgewood Pharmacy. Dogs taking trilostane also experience increased energy in most cases.
Features
-
Veterinarians typically prescribe trilostane for use once or twice per day, with the dosage varying depending upon the dog's weight and the severity of the condition, reports Mar Vista Animal Medical Center.
Risks
-
Approximately 2 to 3 percent of dogs treated with trilostane for canine Cushing's disease develop Addison's disease, a life-threatening condition, in which the adrenal glands fail to function properly.
-