Canine Side Effects of Chloramphenicol

Chloramphenicol, also referred to as CHPC, is a powerful antibiotic most often given to dogs that have pneumonia, an infection of the nervous system, eye infections, and certain parasites. It may be administered in the form of a tablet or a topical cream, but the side effects will remain the same. Not all dogs experience side effects when taking Chloramphenicol, and severe side effects are rare.

  1. Nausea

    • A dog given Chloramphenicol may experience mild or moderate nausea, which may result in vomiting. If this is the case, consult with your vet about receiving an alternative medication.

    Diarrhea

    • Diarrhea is a common side effect of Chloramphenicol in canines. If experienced, the veterinarian may be able to prescribe a different medication to relieve the problem. Prolonged diarrhea may result in dehydration or an electrolyte imbalance, so prompt treatment is necessary.

    Appetite Loss

    • Dogs that are given Chloramphenicol may experience a loss of appetite. They may only eat small amounts of food or may refuse to eat at all. If that is the case, consult with the prescribing veterinarian for a change in medication, as prolonged loss of appetite could result in malnourishment.

    Toxic Accumulation

    • Puppies are not able to digest and process Chloramphenicol the same way an adult canine can. This can lead to toxic accumulation of the medicine in the puppy's body. Do not give the medication to a pregnant dog, as it will be passed onto the fetus and could result in death.

    Blood Dyscrasias

    • Blood dyscrasias is a rare side effect in which the Chloramphenicol affects a dog's bone marrow. With this condition, the dog's body cannot create new blood cells, or any new cells will be abnormal and make the dog sick. This side effect is not a major concern, but it is important to make sure your dog does not overdose on the medication.