Lupus is an autoimmune disorder in which the body misidentifies part of itself as "foreign," releasing antibodies to attack that part of the body. Although uncommon in dogs, it does occur in two forms. Systemic lupus erythematosus (SLE) attacks the vital systems and organs of your dog's body, especially the kidneys, joints, heart and lungs. Discoid lupus attacks only the tissues of your dog's face. Because lupus manifests itself in varying ways and the symptoms often appear and disappear, it is difficult to diagnose. But it's possible to notice these subtle and shifting signs.
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General Malaise
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You may notice that your dog is lethargic, uninterested in normal activities or unwilling to do as asked. He may also be sleeping more than usual.
Lameness
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Your dog may exhibit, a "rotating" lameness, in which she limps on one leg for a while and then she begins to limp on a different leg.
Fever
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Your dog may have fevers that seemingly come and go without explanation.
Kidney Problems
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If the antibodies are attacking your dog's kidneys, you will initially notice that he is drinking and urinating more than usual. If allowed to progress, symptoms will include loss of appetite, weight loss, vomiting, diarrhea, foul breath and lethargy.
Skin and Tissue Infection
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If the antibodies attack your dog's skin, typically her face and feet that will exhibit the first signs. Your dog may lose her fur, develop oral ulcers or pale gums, or her nose may become bumpy, flaky and spattered with sores.
Inflammation Of Heart and Lung Tissue
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Although less common, your dog may experience inflammation of the heart muscle (myocarditis), the lining of the heart (pericarditis) or the lining of the lungs (pleuritis). In reaction to the inflammation he may develop a fever, have seizures or display behavioral changes.
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