Over the counter medications can be effective for the treatment of pain of arthritis but there are some significant differences between Tylenol (acetaminophen) and the non steroidal anti inflammatory drugs (NSAIDs) such as ibuprofen, naproxen and aspirin.
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Pain
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All of the NSAIDs and the medication contained in Tylenol are approved for the treatment of mild to moderate pain, including arthritis pain.
Inflammation
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NSAIDs are anti-inflammatory drugs and work to reduce inflammation of arthritis by inhibiting the cyclooxygenase (COX) enzyme. Tylenol does not have this effect and is not considered to be effective at treating inflammation.
Side Effects
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NSAIDs are known to cause stomach upset and may be damaging to the kidneys when taken in large doses. Tylenol does not generally cause stomach upset or kidney damage but is known to be damaging to the liver when taken in high doses or for long periods of time.
Drug Interactions
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NSAIDs may interact with certain blood pressure medications. Tylenol may interact with drugs that are metabolized by the liver and should not be taken if consuming alcohol or other products containing acetaminophen.
Duration of Action
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Though there is an "extended release" form of Tylenol, regular Tylenol is considered to be effective for foru to six hours. Aspirin and ibuprofen (Advil) may be effective for four to eight hours while naproxen (Alleve) has a duration of action of 8 to 12 hours, which may make it more convenient for someone with a chronic condition such as arthritis.
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