Atypical Cushing's Disease in a Canine

Dogs suffer from the same diseases that afflict humans. Cushing̵7;s disease is one ailment that can affect any living creature with an endocrine system. Atypical Cushing̵7;s disease is one variant of the disease, along with typical and pseudo-Cushing̵7;s disease.

  1. Symptoms

    • Atypical Cushing̵7;s disease is a form of Hyperadrenocorticism (HAC). This endocrine disorder causes a dog to drink excessively, urinate often, lose hair and become weak and tired.

    Identification

    • Cushing̵7;s disease occurs when the adrenal gland secretes an excess of adrenocorticotropic hormone (ACTH). Veterinarians use the word atypical when tests for Cushing̵7;s disease, such as ACTH tests and low dose dexamethasone suppression (LDDS) tests, come out normal.

    Cause

    • According to Rhett Nichols, DVM, ACVIM, there is speculation that atypical Cushing̵7;s disease occurs because of an abnormality in the production of steroids that are needed to make cortisol, the hormone released by the adrenal gland.

    Dogs at Risk

    • Cushing̵7;s disease normally affects dogs older than 8 years old. Many die within two years of diagnosis either from old age or other infections caused by the disease.

    Treatment

    • There is limited treatment for atypical Cushing̵7;s disease. Mitotane or trilostane may be administered.