L-asparaginase is a chemotherapeutic agent used for the treatment of lymphosarcoma, lymphocytic leukemias and mast cell tumors in dogs. Although side effects are rare, some dogs may experience one or more problems as a result of treatment with this medication.
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Allergic Reaction
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Allergic reactions, which rarely occur at home, will normally be seen within 15 to 30 minutes of initial treatment. Symptoms include red, itchy skin or hives, facial swelling, panting, shaking and collapse.
Vomiting
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If vomiting occurs, remove food and water for 12 hours, then slowly reintroduce water. If your dog does not vomit when given water, you can begin to reintroduce food. If vomiting continues or there are more than two vomiting episodes, contact your veterinarian.
Diarrhea
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Your dog may experience loose stool. If so, feed her a bland diet consisting of boiled chicken or rice for a couple of days. If the diarrhea is bloody or very runny or lasts longer than 24 hours, contact your veterinarian.
Lethargy
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Lethargy accompanied by vomiting or diarrhea could indicate that your dog has an infection or is dehydrated. Hospital treatment may be necessary.
Loss of Appetite
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If your dog does not have an good appetite, try feeding him boiled chicken. If he has not eaten for 24 hours or is lethargic as well, contact your veterinarian.
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