Vetoryl For Canine Cushing's Disease

Canine Cushing's disease (or hyperadrenocorticism) is a serious condition where the dog's body makes high levels of the hormone cortisol. Vetoryl is the brand name for trilostane and the only licensed treatment in the United States for canine Cushing's.

  1. Types

    • There are two types of Cushing's syndrome in dogs--pituitary-dependent and adrenal-dependent. The Federal Drug Administration (FDA) has approved Vetoryl for both types.

    Function

    • According to Barbara Forney, VMD, Vetoryl prevents the adrenal gland from making an enzyme called 3-beta hydroxysteroid dehydrogenase, which helps stop the process of making cortisol.

    Consideration

    • Dechra, the makers of Vetoryl, recommend that dogs suspected of having Cushing's disease undergo either an ACTH stimulation test or a low-dose dexamethasone suppression test before being given a first dose of Vetoryl to be sure the dog does not have another illness.

    Dosage

    • The FDA recommends a starting dose of 1 to 3 milligrams per pound that the dog weighs. Give the medication once a day with food.

    Side Effects

    • Dr. Forney notes that common side effects of dogs with Cushing's on Vetoryl include drowsiness, diarrhea, vomiting, refusal to eat. A drop in body salts (hyponatremia) or blood potassium (hypokalemia) can also occur. Call your vet should any unusual symptoms appear.