What can you do for a two year old dog who has never been in heat?

There is no such thing as a two year old dog who has never been in heat.

All female dogs go into heat as part of their reproductive cycle, typically beginning at around six to twelve months of age. If you have a two-year-old female dog that has not yet gone into heat, it is important to take her to a veterinarian to determine the cause. There may be an underlying medical condition that is preventing her from going into heat, or she may be a late bloomer.