When Gram-negative bacteria are destroyed, endotoxins are released into the surrounding environment. In small amounts, endotoxins can be cleared by the immune system without causing any problems. However, in large amounts, endotoxins can trigger a cascade of inflammatory events that can lead to endotoxic shock.
The inflammatory response to endotoxins is mediated by a number of different factors, including cytokines, chemokines, and nitric oxide. These substances can cause a number of symptoms, including fever, chills, tachycardia, hypotension, and organ failure. In severe cases, endotoxic shock can be fatal.
Risk factors for endotoxic shock:
- Infection with Gram-negative bacteria
- Compromised immune system
- Advanced age
- Underlying medical conditions
Endotoxic shock is a serious medical condition that requires prompt treatment. If you think you may be experiencing endotoxic shock, seek medical attention immediately.