Why anti IgE treatment is effective?

Anti-IgE treatment is effective in treating allergic diseases because it blocks the action of immunoglobulin E (IgE), an antibody that plays a key role in the allergic response. When an allergen binds to IgE molecules bound to mast cells and basophils, it triggers the release of histamine and other inflammatory mediators, leading to allergy symptoms such as sneezing, runny nose, watery eyes, and itching.

By blocking IgE, anti-IgE treatment prevents the allergen from binding to IgE and activating mast cells and basophils, thereby inhibiting the release of inflammatory mediators and preventing the development of allergy symptoms.

Here are some specific mechanisms by which anti-IgE treatment works:

Neutralization of IgE: Anti-IgE antibodies bind to IgE molecules, preventing them from binding to allergens. This prevents the crosslinking of IgE molecules on the surface of mast cells and basophils, which is necessary for the release of inflammatory mediators.

Reduction of IgE levels: Anti-IgE treatment can reduce the total levels of IgE in the blood by promoting the breakdown and clearance of IgE antibodies. This decreases the number of IgE molecules available to bind to allergens and trigger the allergic response.

Inhibition of IgE production: Anti-IgE treatment can inhibit the production of IgE antibodies by B cells. This reduces the number of IgE molecules available to bind to allergens and trigger the allergic response.

Modulation of immune responses: Anti-IgE treatment can modulate immune responses by altering the balance between Th1 and Th2 immune cells. Th2 cells are primarily responsible for allergic responses, while Th1 cells are involved in cell-mediated immunity. Anti-IgE treatment can promote a shift from a Th2-dominant to a Th1-dominant immune response, which can help to reduce allergy symptoms.

Overall, anti-IgE treatment is effective in treating allergic diseases by blocking the action of IgE and preventing the development of allergy symptoms.