- Increased risk of genetic disorders, such as hip dysplasia, eye problems, and heart defects.
- Reduced genetic diversity, which can lead to a decrease in the overall health and fitness of the population.
- Increased risk of autoimmune diseases, which occur when the body's immune system attacks its own tissues.
- Increased risk of reproductive problems, such as infertility and stillbirth.
For these reasons, it is generally recommended to avoid breeding grandmother dogs with their grandsons, as well as any other closely related animals. If you are considering breeding your dog, it is important to talk to a qualified veterinarian or breeder about the potential risks and benefits involved.