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Fipronil
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Frontline Plus contains fipronil, which is a manufactured insecticide that works on a cellular level on adult fleas and ticks. It seeps into the cells and blocks chlorine molecules from passing into the cell. This stops the nervous system from working and paralyzes the insect. Because fipronil is so strong, it only needs to be applied once a month to continuously kill fleas and ticks. Once it is applied with an oily liquid to keep it on the skin of the dog or cat, it slowly seeps into the hair follicles and the oil glands of the animal where the fleas and ticks live.
Methoprene
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The other active ingredient in Frontline Plus is methoprene. It is an insect growth regulator or IGR. This ingredient works by affecting the eggs and larvae of fleas, not the adults. An IGR acts like the flea's growth hormone, the substance that allows a flea to grow into an adult. Methoprene interrupts the normal levels of growth hormone, which makes the juvenile flea stop growing. It does not go through the molting stage, which makes it die. Frontline Plus contains methoprene to stop the juvenile cycle and fipronil to stop the adults.
Cautions
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Because fipronil and methoprene are strong, powerful insecticides, take precautions when using Frontline Plus. Always point the applicator away from your face, especially the eyes, and wash hands thoroughly after applying the medicine. Watch for any signs of allergic reaction in the cat or dog that has received a dose of Frontline Plus. Some animals are sensitive or allergic to the ingredients, and that means the active ingredients as well as the nonactive ingredients. If the animal shows signs of itching, restlessness, vomiting, lethargy or difficulty breathing, take it to the veterinarian immediately.
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