- Coyotes: Coyotes are known to hunt and kill muskrats for food.
- Foxes: Foxes are another predator that preys on muskrats.
- Owls: Owls are nocturnal predators that often hunt muskrats at night.
- Snakes: Snakes, such as the cottonmouth and the water moccasin, can also prey on muskrats.
- Alligators: Alligators are found in many of the same areas as muskrats and will often prey on them.
- Humans: Humans are also a significant predator of muskrats, hunting them for their fur and meat.