- Wolves: Wolves are the primary predator of caribou in North America. They are opportunistic predators that will hunt caribou of all ages, but they tend to focus on calves and yearlings. Wolves typically hunt in packs, and they can bring down even healthy adult caribou.
- Bears: Bears are also important predators of caribou. Grizzly bears and black bears both prey on caribou, and they can kill calves, yearlings, and even adult caribou. Bears are typically solitary hunters, but they may sometimes hunt in pairs.
- Wolverines: Wolverines are small, but they are fierce predators. They prey on caribou calves and yearlings, and they can also kill adult caribou if they are sick or injured. Wolverines are typically solitary hunters, but they may sometimes hunt in pairs.
- Cougars: Cougars are predators of caribou in North America. They typically prey on calves and yearlings, but they can also kill adult caribou. Cougars are typically solitary hunters, but they may sometimes hunt in pairs.
- Humans: Humans are also predators of caribou. Caribou are hunted for food, sport, and fur. In some areas, caribou hunting is a major source of food for indigenous people.