1. Felids: Jaguars, ocelots, margays, and other feline species.
2. Canids: Wolves, coyotes, foxes, and other canine predators.
3. Mustelids: Weasels, skunks, tayras and other members of the mustelid family.
4. Birds of Prey: Eagles, hawks, owls, and other raptorial birds.
5. Large Snakes: Boas, anacondas and other large snakes that can constrict agoutis.
6. Crocodilians: In areas with suitable habitats, crocodiles and alligators can prey on agoutis that come near water bodies.
7. Wild Boars: In some regions, feral pigs can be significant predators of agoutis, especially for their young.
Agoutis employ various defense mechanisms to avoid predators, such as their agility and ability to seek refuge in dense vegetation. However, their abundance in different ecosystems is also influenced by the presence and abundance of their predators.