- The Hispaniolan solenodon: This small, shrew-like mammal is found only in the Dominican Republic and Haiti. It is the last surviving member of the family Solenodontidae.
- The Jamaican iguana: This large lizard is found only in Jamaica. It is one of the largest lizards in the Caribbean, and can grow up to 6 feet long.
- The Mona Island boa: This large snake is found only on Isla Mona, a small island off the coast of Puerto Rico. It is the second-largest snake in the Caribbean, and can grow up to 10 feet long.
- The Cuban solenodon: This small, shrew-like mammal is found only in Cuba. It is the last surviving member of the family Solenodontidae.
- The Puerto Rican parrot: This brightly-colored parrot is found only in Puerto Rico. It is the last remaining species of parrot that is endemic to the Caribbean.
- The West Indian manatee: This large, gentle mammal is found in coastal waters throughout the Caribbean Sea. It is one of the most iconic animals in the region, and is a popular tourist attraction.
- The American crocodile: This large reptile is found in saltwater habitats throughout the Caribbean Sea. It is the largest native species of crocodile in the Americas, and can grow up to 17 feet long.