- Owls: Several owl species, including powerful owls, barn owls, and masked owls, are known to hunt cuscuses in their natural habitats.
- Snakes: Large snakes, such as pythons and tree snakes, are skilled predators that can ambush and consume cuscuses.
- Wildcats: Depending on the region, different species of wildcats may prey on cuscuses, including spotted-tail quolls, northern quolls, and tiger quolls.
- Birds of prey: Some larger birds of prey, such as hawks and eagles, can hunt cuscuses, particularly in exposed or open areas.
- Dingoes: In Australia, dingoes are known to be significant predators of cuscuses, especially on smaller islands or areas where dingo populations are higher.
- Introduced species: In regions where invasive species have been introduced, such as feral cats, dogs, or mongooses, they can pose additional threats to cuscus populations.
- Humans: In certain areas, human hunting or habitat modification can also impact cuscus populations and increase their vulnerability to predators.
The presence and abundance of these predators can vary depending on the cuscus species and their geographical distribution. Conservation efforts often focus on managing and reducing the impacts of predators to ensure the survival of cuscus populations.