Here's why:
* Different species: Beef cattle (Bos taurus) and buffalo (Bubalus bubalis) are different species. While they are both members of the Bovidae family, they are too genetically distinct to produce viable offspring.
* Chromosomal differences: Cattle and buffalo have a different number of chromosomes, which are the structures that carry genetic information. This difference makes it impossible for their DNA to properly combine and form a viable embryo.
What about "beefalo"?
While the term "beefalo" exists, it refers to a hybrid animal created through breeding a domestic cow with a domestic buffalo. But even these hybrids are often infertile.
In short: While it's a fun thought experiment, trying to breed a beef bull with a buffalo cow would not result in a healthy offspring.