Black-footed ferrets hunt by locating and entering prairie dog burrows. They use their keen sense of hearing and smell to detect the presence of prairie dogs underground. Once inside a burrow, the ferret will search for and attack its prey. They are efficient predators and can kill multiple prairie dogs in a single hunting session.
In addition to prairie dogs, black-footed ferrets may occasionally consume other small mammals such as ground squirrels, mice, and voles. They have also been known to eat birds, insects, and lizards, although these items make up a small portion of their diet.
The black-footed ferret's reliance on prairie dogs as a primary food source makes them highly specialized predators. Their conservation status is closely linked to the availability and abundance of prairie dog colonies. The decline of prairie dog populations due to habitat loss, disease, and control efforts has had a significant impact on the black-footed ferret population and has contributed to their endangered status.