When was fibrinogen first isolated from horse plasma?

While fibrinogen was discovered in the 1800s, the first isolation from horse plasma isn't specifically documented. However, we can trace the discovery and early isolation back to these key points:

* 1856: Alexander Schmidt (German physiologist) first isolated fibrinogen from human blood plasma. He also observed the conversion of fibrinogen to fibrin during clotting.

* Early 1900s: Researchers continued to refine techniques for isolating fibrinogen from various animal sources, including horse plasma. While specific dates for horse plasma isolation aren't readily available, the focus shifted towards understanding the clotting process and its components.

Therefore, while a precise date for the first isolation of fibrinogen from horse plasma is unavailable, it likely occurred during the early 1900s, building upon Schmidt's initial work.

If you're looking for a specific study or publication about the isolation of fibrinogen from horse plasma, you might need to consult historical scientific literature or specific databases specializing in the history of medicine and biology.