* Lionfish are typically found in shallower, warmer waters. Great white sharks prefer cooler, deeper waters. Their ranges rarely overlap.
* Lionfish are venomous. While not deadly to humans, the venom could cause discomfort for a shark, and they likely wouldn't find the risk worth the reward.
* Lionfish are small compared to the prey great whites typically eat. They focus on larger marine mammals, seals, and other sharks.
While it's theoretically possible a great white might encounter and eat a lionfish in a rare circumstance, it's highly unlikely.