- Killer whales (Orcas): Orcas are highly intelligent and social predators known for hunting in pods and employing various hunting techniques. they are known to target and feed on great white sharks.
- Larger great white sharks: Sometimes, larger great white sharks may prey upon smaller individuals of the same species. This behavior is known as cannibalism and typically occurs when food resources are scarce.
- Humans: Humans are the greatest predators of great white sharks. Hunting and fishing activities over the years have led to population decline in some regions.