- Killer whales (Orcinus orca): Killer whales are apex predators that hunt a wide variety of marine mammals, including sea mink.
- Stellar sea lions (Eumetopias jubatus): Stellar sea lions are large marine mammals that prey on various species, including sea mink.
- Bears (Ursus spp.): Bears, particularly brown bears (Ursus arctos), were likely predators of sea mink when the latter inhabited coastal areas.
- Wolves (Canis lupus): Wolves, especially those inhabiting coastal regions, may have occasionally hunted sea mink.
- Eagles (Haliaeetus spp.): Some eagle species, such as bald eagles (Haliaeetus leucocephalus), may have preyed on young or vulnerable sea mink individuals.
- Land Otters (Lontra canadensis): Although their diets usually consist of aquatic invertebrates and fish, some land otters may have seen sea mink as an occasional prey species.