- Fossas: Fossas are cat-like carnivores that are native to Madagascar. They are the largest predators on the island, and they are known to prey on sifakas.
- Boas: Boas are large snakes that are also native to Madagascar. They are known to prey on sifakas, and they can even eat adult sifakas.
- Harrier hawks: Harrier hawks are birds of prey that are found in Madagascar. They are known to prey on sifakas, and they can even take down adult sifakas.
- Humans: Humans are also predators of sifakas. Sifakas are hunted for their meat and their fur, and they are also sometimes killed as pests.