- Fur trade: Giant otters have valuable fur, which is used to make coats, hats, and other clothing items. In the past, giant otters were heavily hunted for their fur, and their populations were severely depleted. Although the fur trade is still a threat to giant otters, it is not as significant as it once was.
- Meat: Giant otters are sometimes hunted for their meat. Their meat is considered to be a delicacy in some cultures, and it is sold in local markets.
- Bycatch: Giant otters are also sometimes killed as bycatch. This occurs when giant otters are accidentally caught in fishing nets or traps that are set for other animals. Bycatch is a significant threat to giant otters, and it is estimated that thousands of giant otters are killed each year in this way.
- Habitat destruction: Habitat destruction is another major threat to giant otters. Giant otters rely on healthy rivers and wetlands for survival, but these habitats are being destroyed at an alarming rate due to human activities such as deforestation, pollution, and dam construction. Giant otters are often killed when their habitats are destroyed.