Can vaccines make white cells go up?

Vaccines typically do not cause a significant increase in the number of white blood cells in the body, but rather stimulate the production of specific antibodies to fight off particular diseases. While some vaccines can cause a temporary elevation of white blood cell counts as part of the body's immune response, this is a transient effect that usually resolves within a short period of time. Vaccines work primarily by introducing a weakened or inactivated form of a virus or bacteria into the body, allowing the immune system to develop antibodies against it without causing the person to become ill with the disease.