* Species: Wild rabbits (like the Eastern Cottontail) and domestic rabbits (like the minilop) are different species. While they share a common ancestor, they have diverged enough over time to be considered distinct species.
* Genetics: Species have different chromosome numbers and structures, making it impossible for their genes to combine properly. This prevents successful fertilization and offspring development.
In summary: Even if a wild rabbit and a minilop were to mate, they would not produce offspring.