* Different species: While both are cats, cheetahs and lions are distinct species with significant genetic differences. This makes successful mating nearly impossible.
* Behavioral differences: They have very different behaviors, habitats, and social structures. Cheetahs are solitary hunters, while lions live in prides.
* Physical incompatibility: There are anatomical differences that would make mating difficult, even if they were willing.
What about in captivity?
While theoretically possible, it's extremely rare and unethical to attempt such a cross between species in captivity. The offspring, if produced, would likely be infertile and suffer from health issues due to the genetic mismatch.
The bottom line:
Nature has its own boundaries, and cheetah-lion hybrids are simply not meant to be.