- Woolly Mammoth (_Mammuthus primigenius_) - Extinct around 10,000 years ago.
- Saber-Toothed Tiger (_Smilodon fatalis_) - Extinct around 10,000 years ago.
- Giant Ground Sloth (_Megalonyx jeffersonii_) - Extinct around 10,000 years ago.
- Dodo Bird (_Raphus cucullatus_) - Extinct around 1662.
- Passenger Pigeon (_Ectopistes migratorius_) - Extinct in 1914.
- Great Auk (_Pinguinus impennis_) - Extinct in 1844.
- Tasmanian Tiger (_Thylacinus cynocephalus_) - Extinct in 1936.
- Baiji (_Lipotes vexillifer_) - Extinct in 2006.
- Spix's Macaw (_Cyanopsitta spixii_) - Extinct in the wild, possibly extinct in captivity.
- Northern White Rhinoceros (_Ceratotherium simum cottoni_) - Only two individuals remain.