- Harpy eagles (Harpia harpyja): These large, powerful birds of prey are known to hunt toco toucans and other large birds. They use their sharp talons to grasp their prey and carry it away to their nests.
- Jaguarundis (Puma yagouaroundi): Jaguarundis are small, cat-like predators that are found in Central and South America. They are known to prey on toco toucans and other small animals.
- Ocelots (Leopardus pardalis): Ocelots are medium-sized cats that are found in Central and South America. They are known to prey on toco toucans and other small animals.
- Boa constrictors (Boa constrictor): Boa constrictors are large, non-venomous snakes that are found in Central and South America. They are known to prey on toco toucans and other small animals.
- Humans: Humans are also known to hunt toco toucans for their meat, feathers, and beaks.