- Snakes: Various snakes, such as black rat snakes, corn snakes, and timber rattlesnakes, prey on Eastern Gray Squirrels. Snakes ambush the squirrels and use constriction to kill them.
- Birds of Prey: Birds of prey, such as hawks, eagles, and owls, hunt and capture Eastern Gray Squirrels. These birds have sharp talons and beaks that allow them to seize and kill the squirrels.
- Carnivores: Carnivorous mammals, such as coyotes, foxes, raccoons, and weasels, also prey on Eastern Gray Squirrels. These predators use their speed, agility, and sharp teeth to hunt and kill the squirrels.
In addition to these natural predators, Eastern Gray Squirrels may also face threats from human activities, such as habitat loss, hunting, and road accidents. Understanding and managing these various threats is important for conserving and protecting Eastern Gray Squirrel populations.